SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549



                                    Form 11-K


(Mark One)

( X )    Annual report pursuant to Section 15(d) of the Securities Exchange Act
         of 1934 (Fee Required)
         For the fiscal year ended December 31, 1996 or
                                   -----------------


(  )     Transition report pursuant to Section 15(d) of the Securities Exchange
         Act of 1934 (No Fee Required)         
         For the transition period from ____ to ____


Commission File Number 0-16109








                         ADVANCED POLYMER SYSTEMS, INC.
                      SALARY REDUCTION PROFIT SHARING PLAN











                         ADVANCED POLYMER SYSTEMS, INC.
                                3696 Haven Avenue
                         Redwood City, California 94063
                            Telephone: (415) 366-2626






Financial Statement and Exhibits

                                                   ADVANCED POLYMER SYSTEMS, INC.
                                                SALARY REDUCTION PROFIT SHARING PLAN

                                                  STATEMENT OF FINANCIAL CONDITION
                                                        at December 31, 1996
Nationwide Nationwide Nationwide Warburg American Bond Templeton Fidelity Twentieth Pincus Balanced Fund of Foreign Magellan Century Emerging Fund America Fund Fund Growth Growth ---------- ---------- ---------- ---------- ---------- ---------- ASSETS: Cash account $ 0 $ 0 $ 0 $ 0 $ 0 $ 0 Investments, at market 393,452 182,926 0 241,543 617,549 0 Participant loans 0 0 0 0 0 0 Contributions receivable 4,066 1,721 1,832 5,118 5 ,930 1,205 ---------- ---------- ---------- ---------- ---------- ---------- TOTAL ASSETS $ 397,518 $ 184,647 $ 1,832 $ 246,661 $ 623,479 $ 1,205 ========== ========== ========== ========== ========== ========== LIABILITIES: Distribution payable $ 0 $ 0 $ 0 $ 0 $ 0 $ 0 ---------- ---------- ---------- ---------- ---------- ---------- TOTAL LIABILITIES 0 0 0 0 0 0 PLAN EQUITY: Salary reduction accounts 332,016 154,357 0 195,405 522,137 0 Employer matching accounts 65,502 30,290 1,832 51,256 101,342 1,205 ---------- ---------- ---------- ---------- ---------- ---------- TOTAL EQUITY 397,518 184,647 1,832 246,661 623,479 1,205 TOTAL LIABILITIES AND EQUITY $ 397,518 $ 184,647 $ 1,832 $ 246,661 $ 623,479 $ 1,205 ========== ========== ========== ========== ========== ==========
Nationwide Guaranty APS Total and Savings Common Participant All Fund Stock Loans Funds ---------- ---------- ---------- ---------- ASSETS: Cash account $ 5,887 $ 0 $ 0 $ 5,887 Investments, at market 390,911 67,489 0 1,893,870 Participant loans 0 0 11,128 11,128 Contributions receivable 3,787 1,378 0 25,037 ---------- ---------- ---------- ---------- TOTAL ASSETS $ 400,585 $ 68,867 $ 11,128 $1,935,922 ========== ========== ========== ========== LIABILITIES: Distribution payable $ 0 $ 0 $ 0 $ 0 ---------- ---------- ---------- ---------- TOTAL LIABILITIES 0 0 0 0 PLAN EQUITY: Salary reduction accounts 323,798 55,454 11,128 1,594,295 Employer matching accounts 76,787 13,413 0 341,627 ---------- ---------- ---------- ---------- TOTAL EQUITY 400,585 68,867 11,128 1,935,922 TOTAL LIABILITIES AND EQUITY $ 400,585 $ 68,867 $ 11,128 $1,935,922 ========== ========== ========== ========== See accompanying notes. Financial Statement and Exhibits ADVANCED POLYMER SYSTEMS, INC. SALARY REDUCTION PROFIT SHARING PLAN STATEMENT OF FINANCIAL CONDITION at December 31, 1995
Nationwide Nationwide Nationwide Nationwide American Bond Fidelity Twentieth Guaranty APS Total Balanced Fund of Magellan Century and Savings Common Participant All Fund America Fund Growth Fund Stock Loans Funds ------------- ----------- ----------- ------------------------------------- ------------ ----------- ASSETS: Cash account $0 $0 $0 $0 $7,114 $0 $0 $7,114 Investments, at market 293,031 156,631 122,349 491,553 352,975 33,808 0 1,450,347 Participant loans 0 0 0 0 0 0 6,531 6,531 Contributions receivable 3,458 2,570 8,911 6,582 5,583 1,254 0 28,358 -------- -------- -------- -------- -------- ------- ------ ---------- TOTAL ASSETS $296,489 $159,201 $131,260 $498,135 $365,672 $35,062 $6,531 $1,492,350 ======== ======== ======== ======== ======== ======= ====== ========== LIABILITIES: Distributions payable $0 $0 $0 $0 $0 $0 $0 $0 -------- -------- -------- -------- -------- ------- ------ ---------- TOTAL LIABILITIES $0 $0 $0 $0 $0 $0 $0 $0 PLAN EQUITY: Salary reduction accounts 250,543 135,232 104,974 420,447 301,560 28,418 6,531 1,247,705 Employer matching accounts 45,946 23,969 26,286 77,688 64,112 6,644 0 244,645 -------- -------- -------- -------- -------- ------- ------ ---------- TOTAL EQUITY 296,489 159,201 131,260 498,135 365,672 35,062 6,531 1,492,350 TOTAL LIABILITIES AND EQUITY $296,489 $159,201 $131,260 $498,135 $365,672 $35,062 $6,531 $1,492,350 ======== ======== ======== ======== ======== ======= ====== ========== See accompanying notes.
ADVANCED POLYMER SYSTEMS, INC. SALARY REDUCTION PROFIT SHARING PLAN STATEMENT OF INCOME AND CHANGES IN PLAN EQUITY for the year ended December 31, 1996
Nationwide Nationwide Nationwide American Bond Templeton Fidelity Twentieth Balanced Fund of Foreign Magellan Century Fund America Fund Fund Growth ----------- ----------- ----------- ----------- ----------- Investment income: Interest and dividends $ 0 $ 0 $ 0 $ 0 $ 0 ----------- ----------- ----------- ----------- ----------- Total investment income 0 0 0 0 0 ----------- ----------- ----------- ----------- ----------- Net realized and unrealized gains on investments 37,966 8,749 0 19,348 68,997 ----------- ----------- ----------- ----------- ----------- Contributions: Employee 53,948 23,696 0 88,164 77,480 Employer 16,724 7,582 1,832 27,347 24,837 Rollovers 5,058 14 0 4,936 11,964 ----------- ----------- ----------- ----------- ----------- Total contributions 75,730 31,292 1,832 120,447 114,281 ----------- ----------- ----------- ----------- ----------- Withdrawals, transfers and distributions: Member accounts withdrawn & distributed (14,487) (10,488) 0 (23,534) (56,696) Member accounts transferred-in (out) 1,820 (4,107) 0 (860) (1,238) ----------- ----------- ----------- ----------- ----------- Net withdrawals, transfers and distributions (12,667) (14,595) 0 (24,394) (57,934) ----------- ----------- ----------- ----------- ----------- Net increase in plan equity 101,029 25,446 1,832 115,401 125,344 Plan equity: Beginning of the year 296,489 159,201 0 131,260 498,135 ----------- ----------- ----------- ----------- ----------- End of the year $ 397,518 $ 184,647 $ 1,832 $ 246,661 $ 623,479 =========== =========== =========== =========== ===========
Warburg Nationwide Pincus Guaranty APS Total Emerging and Savings Common Participant All Growth Fund Stock Loans Funds ----------- ----------- ----------- ----------- ----------- Investment income: Interest and dividends $ 0 $ 19,981 $ 0 $ 781 $ 20,762 ----------- ----------- ----------- ----------- ----------- Total investment income 0 19,981 0 781 20,762 ----------- ----------- ----------- ----------- ----------- Net realized and unrealized gains on investments 0 0 13,150 0 148,210 ----------- ----------- ----------- ----------- ----------- Contributions: Employee 0 61,207 16,439 0 320,934 Employer 1,205 20,393 5,511 0 105,431 Rollovers 0 2,873 0 0 24,845 ----------- ----------- ----------- ----------- ----------- Total contributions 1,205 84,473 21,950 0 451,210 ----------- ----------- ----------- ----------- ----------- Withdrawals, transfers and distributions: Member accounts withdrawn & distributions 0 (66,590) (4,815) 0 (176,610) Member accounts transferred-in (out) 0 (2,951) 3,520 3,816 0 ----------- ----------- ----------- ----------- ----------- Net withdrawals, transfers and distributions 0 (69,541) (1,295) 3,816 (176,610) ----------- ----------- ----------- ----------- ----------- Net increase in plan equity 1,205 34,913 33,805 4,597 443,572 Plan equity: Beginning of the year 0 365,672 35,062 6,531 1,492,350 ----------- ----------- ----------- ----------- ----------- End of the year $ 1,205 $ 400,585 $ 68,867 $ 11,128 $ 1,935,922 =========== =========== =========== =========== =========== See accompanying notes
ADVANCED POLYMER SYSTEMS, INC. SALARY REDUCTION PROFIT SHARING PLAN STATEMENT OF INCOME AND CHANGES IN PLAN EQUITY for the year ended December 31, 1995
Nationwide Nationwide Nationwide Nationwide American Bond Fidelity Twentieth Guaranty APS Total Balanced Fund of Magellan Century and Savings Common Participant All Fund America Fund Growth Fund Stock Loans Funds ---------- --------- ---------- ---------- ---------- ---------- ------------ ---------- Investment income: Interest and dividends $0 $0 $0 $0 $18,162 $0 $753 $18,915 ---------- --------- ---------- ---------- ---------- ---------- ------------ ---------- Total investment income 0 0 0 0 18,162 0 753 18,915 ---------- --------- ---------- ---------- ---------- ---------- ------------ ---------- Net realized and unrealized gains on investments 46,387 21,690 26,872 71,238 0 5,247 0 171,434 ---------- --------- ---------- ---------- ---------- ---------- ------------ ---------- Contributions: Employee 43,172 19,728 57,220 61,994 66,221 11,399 0 259,734 Employer 12,777 7,237 20,869 21,815 22,760 4,036 0 89,494 Rollovers 3,458 3,270 2,417 18,285 16,689 0 0 44,119 ---------- --------- ---------- ---------- ---------- ---------- ------------ ---------- Total contributions 59,407 30,235 80,506 102,094 105,670 15,435 0 393,347 ---------- --------- ---------- ---------- ---------- ---------- ------------ ---------- Withdrawals, transfers and distributions: Member accounts withdrawn & distributed (12,848) (20,558) (7,413) (57,690) (22,723) (2,885) 0 (124,117) Member accounts transferred-in (out) 8,919 (9,411) 7,923 (18,312) 20,840 (5,629) (4,330) 0 ---------- --------- ---------- ---------- ---------- ---------- ------------ ---------- Net withdrawals, transfers and distributions (3,929) (29,969) 510 (76,002) (1,883) (8,514) (4,330) (124,117) ---------- --------- ---------- ---------- ---------- ---------- ----------- ---------- Net increase (decrease) in plan equity 101,865 21,956 107,888 97,330 121,949 12,168 (3,577) 459,579 Plan equity: Beginning of the year 194,624 137,245 23,372 400,805 243,723 22,894 10,108 1,032,771 ---------- -------- --------- -------- ---------- ---------- ----------- ----------- End of the year $296,489 $159,201 $131,260 $498,135 $365,672 $35,062 $6,531 $1,492,350 ========= ======== ========= ======== ========== ========= =========== =========== See accompanying notes.
ADVANCED POLYMER SYSTEMS, INC. SALARY REDUCTION PROFIT SHARING PLAN STATEMENT OF INCOME AND CHANGES IN PLAN EQUITY for the year ended December 31, 1994
Nationwide Nationwide Nationwide Nationwide American Bond Fidelity Twentieth Guaranty Balanced Fund of Magellan Century and Savings Fund America Fund Growth Fund ----------- ----------- ----------- ----------- ----------- Investment income: Interest and dividends $ 0 $ 0 $ 0 $ 0 $ 11,201 ----------- ----------- ----------- ----------- ----------- Total investment income 0 0 0 0 11,201 ----------- ----------- ----------- ----------- ----------- Net realized and unrealized gains (losses) on investments (3,954) (8,797) 449 (8,297) 0 ----------- ----------- ----------- ----------- ----------- Contributions: Employee 47,870 22,930 7,831 81,238 54,366 Employer 11,858 6,741 1,396 20,285 12,505 Rollovers 0 0 0 0 0 ----------- ----------- ----------- ----------- ----------- Total contributions 59,728 29,671 9,227 101,523 66,871 ----------- ----------- ----------- ----------- ----------- Withdrawals, transfers and distributions: Member accounts withdrawn (133,785) (31,598) 0 (217,652) (92,441) Distributions 0 0 0 0 (2,005) Member accounts transferred-in (out) (27,892) 18,819 13,696 (43,724) 45,804 ----------- ----------- ----------- ----------- ----------- Net withdrawals, transfers and distributions (161,677) (12,779) 13,696 (261,376) (48,642) ----------- ----------- ----------- ----------- ----------- Net increase (decrease) in plan equity (105,903) 8,095 23,372 (168,150) 29,430 Plan equity: Beginning of the year 300,527 129,150 0 568,955 214,293 ----------- ----------- ----------- ----------- ----------- End of the year $ 194,624 $ 137,245 $ 23,372 $ 400,805 $ 243,723 =========== =========== =========== =========== ===========
APS Total Common Participant All Stock Loans Funds ----------- ----------- ----------- Investment income: Interest and dividends $ 0 $ 966 $ 12,167 ----------- ----------- ----------- Total investment income 0 966 12,167 ----------- ----------- ----------- Net realized and unrealized gains (losses) on investments (3,460) 0 (24,059) ----------- ----------- ----------- Contributions: Employee 9,375 0 223,610 Employer 2,381 0 55,166 Rollovers 0 0 0 ----------- ----------- ----------- Total contributions 11,756 0 278,776 ----------- ----------- ----------- Withdrawals, transfers and distributions: Member accounts withdrawn (21,528) 0 (497,004) Distributions 0 0 (2,005) Member accounts transferred-in (out) (3,149) (3,554) 0 ----------- ----------- ----------- Net withdrawals, transfers and distributions (24,677) (3,554) (499,009) ----------- ----------- ----------- Net increase (decrease) in plan equity (16,381) (2,588) (232,125) Plan equity: Beginning of the year 39,275 12,696 1,264,896 ----------- ----------- ----------- End of the year $ 22,894 $ 10,108 $ 1,032,771 =========== =========== =========== See accompanying notes. ADVANCED POLYMER SYSTEMS, INC. SALARY REDUCTION PROFIT SHARING PLAN Notes to Financial Statements December 31, 1996, 1995 and 1994 1. DESCRIPTION OF THE PLAN The following description of the Advanced Polymer Systems, Inc. Salary Reduction Profit Sharing Plan (the "401(k) Plan" or the "Plan") provides only general information. Members should refer to the 401(k) Plan document for more complete information. (a) General The 401(k) Plan is a defined contribution plan covering active employees of Advanced Polymer Systems, Inc. ("APS" or the "Company") and its subsidiaries. Any employee who is at least 21 years old is eligible to become a voluntary member of the 401(k) Plan immediately upon employment. The 401(k) Plan is subject to the provisions of the Employee Retirement Income Security Act of 1974 ("ERISA"). (b) Contributions - Employee Eligible domestic employees may contribute up to 15% of their total compensation for each calendar year, limited to $9,500 in 1996, and $9,240 in 1995 and 1994 (the "Employee Contribution"). (c) Contributions - Employer For the 1994 Plan year, the Company made matching contributions equal to 50% of each member's Employee Contribution during the Plan year up to a maximum amount equal to the lesser of 1.5% of each member's annual compensation, or $1,000 per calendar year (the "Employer Matching Contribution"). The Company may also contribute additional discretionary amounts as it may determine (the "Employer Discretionary Contribution"). No Employer Discretionary Contributions have been made to the Plan since its inception. Beginning with the 1995 Plan year, the Plan document was amended to change the maximum Employer Matching Contribution to 3% of the participants' annual gross compensation, limited to $4,500. (d) Members' Accounts The Company maintains separate Employee Contribution accounts, Employer Matching Contribution accounts and Employer Discretionary Contribution accounts for each member. Contributions are credited to the member accounts each bi-weekly payroll period. In 1994, the plan trustees added the Fidelity Magellan Fund to the investment options offered to the participants. In 1996, the plan trustees added the Warburg Pincus Emerging Growth Fund and the Templeton Foreign Fund to the investment options offered to the participants. Each member may elect from the following investment options for his/her Employee Contribution accounts: Company Common Stock: The Common Stock of APS will be purchased by the 401(k) Plan's investment manager for the member in a market transaction at the then current market price as quoted on the NASDAQ National Market System. Each member may elect to invest up to 10% of his/her Employee Contributions and Employer Matching Contributions in this option. Warburg Pincus Emerging Growth: A mutual fund seeking capital appreciation by investing primarily in common stock of small and medium size companies that show positive earnings and prospects of achieving significant gains in a relatively short time period. Templeton Foreign: A mutual fund seeking capital growth by investing in stock and debt securities of companies and governments outside of the United States. Fidelity Magellan Fund: A mutual fund seeking capital growth by investing primarily in common stocks and securities convertible into common stock of domestic and foreign multinational issuers of all sizes. Nationwide Twentieth Century Growth: A mutual fund seeking capital growth by investing primarily in common stocks that are considered by fund management to have better-than-average prospects for appreciation. Nationwide American Balanced Fund: A mutual fund seeking conversion of capital, current income and long-term growth of both capital and income through investments in stocks, bonds and other fixed-income securities. Nationwide Bond Fund of America: A mutual fund seeking to provide shareholders as high a level of current income as is consistent with the preservation of capital by investing primarily in bonds such as marketable corporate debt securities, U.S. Government securities, mortgage related securities and cash or money market instruments. Nationwide Guaranty and Savings Fund: Money market funds invested in short-term securities with a guaranteed rate of 5.85% in 1996, 6.1% in 1995 and 5.6% in 1994. Members may change their investment options at specified dates during the Plan year as set forth in the 401(k) Plan document. Income from the selected investments of 401(k) Plan assets is allocated quarterly in the proportion that each member's investment option balance bears to the cumulative balance of each investment option. (e) Vesting The 401(k) Plan provides that the allocated contribution and income of both the Employee Contribution account and the Employer Matching Contribution account are immediately and fully vested. Employer Discretionary Contributions become vested over a period of 6 years in accordance with the following schedule: Years of Service Vested Percentage ---------------- ----------------- Less than 1 0% 1 10% 2 20% 3 40% 4 60% 5 80% 6 or more 100% (f) Withdrawal of Member Accounts The full amounts in a member's accounts, other than the amounts constituting Employer Discretionary Contributions, will be distributed upon retirement (at 62 years of age or if later, the employee's fifth anniversary of employment with the Company), death, or permanent disability of the member. If a member's employment with the Company terminates prior to normal retirement (as defined above) for any reason other than death or disability, the participant will be entitled to a distribution equal to the vested portion of his/her accounts. Members should refer to the 401(k) Plan document for a more complete description of procedures and calculations for the withdrawal of accounts. (g) Trustees The 401(k) Plan is administered by the Company. A Trustee is responsible for investing the assets of the Plan which are held in Trust. The current trustee is Michael O'Connell, Chief Financial Officer of Advanced Polymer Systems, Inc. The Trustee has retained CMG Consulting, Inc. ("CMG") to provide recordkeeping services to the 401(k) Plan. CMG also invests Plan assets in the various mutual funds offered by Nationwide Life Insurance. Members of the Board of Directors and employees of the Company serving as Trustees receive no additional compensation for services in connection with the administration of the 401(k) Plan. (h) Participant Loans Participants are allowed to borrow from the Plan assets. The Plan will allow a participant to borrow up to the lesser of 50% of his/her vested Plan balance or $50,000. The loan, secured by the vested Plan balance of the participant, is repayable in installments over a period up to 5 years at the prime rate plus 2%. The term of the loan can be extended for more than 5 years if the loan is used to purchase the principal dwelling of the participant. 2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (a) Investment Valuation The value of investments is based upon quoted market values on the last business day of the year. (b) Security Transactions and Investment Income Securities transactions are recorded on a trade date basis. The difference between cost and market value of investments at the beginning and end of the period is reported as unrealized appreciation or depreciation in the market value of investments using the average cost method. (c) Expenses of the 401(k) Plan Reasonable fees and expenses incurred in the establishment and administration of the 401(k) Plan, and reasonable compensation of attorneys, accountants, investment managers, actuaries, consultants or expenses of the Trustees or any agent of the Trustees if not employed by the Company will be paid out of the assets of the 401(k) Plan, except to the extent that the Company pays such expenses directly. For the three-year period ended December 31, 1996, all such expenses were paid by the Company. (d) Forfeited Funds If a Participant terminates employment with APS prior to completing six years of service, the unvested portion of such member's Employer Discretionary Contribution account will be forfeited and allocated among the remaining participants in the 401(k) Plan. (e) Basis of Accounting The financial statements are prepared on the accrual basis of accounting. (f) Use of Estimates The preparation of financial statements in conformity with generally accepted accounting principles requires the plan administrator to make estimates and assumptions that affect the amounts reported in the financial statements and related notes to financial statements. Changes in such estimates may affect amounts reported in future periods. 3. INVESTMENTS Investments of the 401(k) Plan at market value as of December 31 are summarized as follows: 1996 1995 ---- ---- Nationwide American Balanced Fund $393,452 $293,031 Nationwide Bond Fund of America 182,926 156,631 Fidelity Magellan Fund 241,543 122,349 Nationwide Twentieth Century Growth 617,549 491,553 Nationwide Guaranty and Savings Fund 390,911 352,975 APS Common Stock 67,489 33,808 Investment option elections of the members of the 401(k) Plan at December 31 are summarized as follows: Number of Participants 1996 1995 ---- ---- Nationwide American Balanced Fund 46 40 Nationwide Bond Fund of America 28 29 Fidelity Magellan Fund 44 33 Nationwide Twentieth Century Growth 53 49 Nationwide Guaranty and Savings Fund 43 43 APS Common Stock 48 39 4. INCOME TAXES APS received a favorable determination from the Internal Revenue Service ("IRS") stating that the 401(k) Plan is qualified under Section 401 of the Internal Revenue Code ("Code") as amended, and is exempt from federal income taxation under Section 501 of the Code. Accordingly, the financial statements do not contain a provision for income taxes. The continued qualification is dependent on the Plan's future operation. Members do not become subject to income taxes as a result of participation in the 401(k) Plan until assets in the members' accounts are distributed. Under certain circumstances, a distribution from the 401(k) Plan is subject to income tax as ordinary income. 5. PLAN TERMINATION Although it has not expressed any intent to do so, APS has the right to terminate the 401(k) Plan at any time. In the event of termination, all accounts will become fully vested, and all net assets will be allocated and distributed to the members based on their respective account balances. 6. SCHEDULE OF MARKETABLE SECURITIES Marketable Securities of the 401(k) Plan at December 31, 1996 and 1995, inclusive of contributions receivable, consisted of the following: Market Units Description Cost Value - ------ ----------- -------- ------ 1996 - ---- 181,182 Nationwide American Balanced Fund $274,841 $397,518 85,433 Nationwide Bond Fund of America 140,188 184,647 1,346 Templeton Foreign Fund 1,832 1,832 123,698 Fidelity Magellan Fund 199,992 246,661 145,470 Nationwide Twentieth Century Growth 435,146 623,479 349,325 Nationwide Guaranty and Savings Fund 332,773 400,585 1,033 Warburg Pincus Emerging Growth 1,205 1,205 9,032 APS Common Stock 52,524 68,867 ---------- ----------- $1,438,501 $1,924,794 1995 - ---- 153,015 Nationwide American Balanced Fund $211,711 $296,489 78,610 Nationwide Bond Fund of America 123,491 159,201 73,602 Fidelity Magellan Fund 103,939 131,260 133,760 Nationwide Twentieth Century Growth 378,666 498,135 337,790 Nationwide Guaranty and Savings Fund 317,841 365,672 6,375 APS Common Stock 31,869 35,062 ---------- ----------- $1,167,517 $1,485,819 INDEPENDENT AUDITORS' REPORT The Board of Directors and Shareholders of Advanced Polymer Systems, Inc. and the Trustees and Participants in the Advanced Polymer Systems, Inc. Salary Reduction Profit Sharing Plan: We have audited the accompanying statements of financial condition of the Advanced Polymer Systems, Inc. Salary Reduction Profit Sharing Plan as of December 31, 1996 and 1995, and the related statements of income and changes in Plan equity for each of the years in the three-year period ended December 31, 1996. These financial statements are the responsibility of the Plan's management. Our responsibility is to express an opinion on these financial statements based on our audits. We conducted our audits in accordance with generally accepted auditing standards. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion. In our opinion, the financial statements referred to above present fairly, in all material respects, the financial position of the Advanced Polymer Systems, Inc. Salary Reduction Profit Sharing Plan as of December 31, 1996 and 1995, and the results of its operations and its changes in Plan equity for each of the years in the three-year period ended December 31, 1996, in conformity with generally accepted accounting principles. KPMG Peat Marwick LLP San Francisco, California March 5, 1997 Exhibits. 23 Consent of Independent Certified Public Accountants SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the trustees (or other persons who administer the plan) have duly caused this annual report to be signed by the undersigned thereunto duly authorized. Advanced Polymer Systems, Inc. Salary Reduction Profit Sharing Plan ------------------------------------ Date: March 26, 1997 /s/ Michael O'Connell ---------------- ------------------------- Michael O'Connell Trustee EXHIBIT INDEX Form 11-K Annual Report ADVANCED POLYMER SYSTEMS, INC. SALARY REDUCTION PROFIT SHARING PLAN 23 Consent of Independent Public Accountants



EXHIBIT 23
CONSENT OF INDEPENDENT CERTIFIED PUBLIC ACCOUNTANTS

The Board of Directors and Shareholders of Advanced  Polymer  Systems,  Inc. and
the Trustees and  Participants  in the Advanced  Polymer  Systems,  Inc.  Salary
Reduction Profit Sharing Plan:


We consent to  incorporation  by reference in the  Registration  Statement  (No.
33-29084) on Form S-8 of the Advanced  Polymer  Systems,  Inc. Salary  Reduction
Profit Sharing Plan of our report dated March 5, 1997 relating to the statements
of financial  condition of the Advanced Polymer  Systems,  Inc. Salary Reduction
Profit Sharing Plan as of December 31, 1996 and 1995 and the related  statements
of income  and  changes in Plan  equity for each of the years in the  three-year
period ended  December 31, 1996,  which report  appears in the December 31, 1996
annual  report  on Form  11-K  of the  Advanced  Polymer  Systems,  Inc.  Salary
Reduction Profit Sharing Plan.



                                                           KPMG Peat Marwick LLP



San Francisco, California
March 26, 1997