UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G

                   UNDER THE SECURITIES EXCHANGE ACT OF 1934

                               A.P. PHARMA, INC.
                                (Name of Issuer)

                                  COMMON STOCK
                         (Title of Class of Securities)

                                   00202J203
                                 (CUSIP Number)

                                  JULY 1, 2011
            (Date of Event Which Requires Filing of this Statement)

Check  the appropriate box to designate the rule pursuant to which this Schedule
is filed:

[X]     Rule 13d-1(b)
[_]     Rule 13d-1(c)
[_]     Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

PERSONS WHO ARE TO RESPOND TO THE COLLECTION OF INFORMATION CONTAINED IN THIS
FORM ARE NOT REQUIRED TO RESPOND UNLESS THE FORM DISPLAYS A CURRENTLY VALID OMB
CONTROL NUMBER.

SEC 1745 (12-02)

-------------------------------------- ------------------------------------- ------------------------------------- CUSIP No. 00202J203 13G Page 2 of 7 Pages -------------------------------------- ------------------------------------- ------------------------------------- --------- -------------------------------------------------------------------------------------------------------- 1. NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) PERCEPTIVE ADVISORS LLC --------- -------------------------------------------------------------------------------------------------------- 2. CHECK THE APPROPRIATE BOX IF A GROUP* (a) [ ] (b) [ ] --------- -------------------------------------------------------------------------------------------------------- 3. SEC USE ONLY --------- -------------------------------------------------------------------------------------------------------- 4. CITIZENSHIP OR PLACE OF ORGANIZATION DELAWARE, UNITED STATES OF AMERICA --------- -------------------------------------------------------------------------------------------------------- ------------------- ---- -------------------------------------------- -------------------------------------------- NUMBER OF SHARES 5. SOLE VOTING POWER 0 ------------------- ---- -------------------------------------------- -------------------------------------------- BENEFICIALLY OWNED BY 6. SHARED VOTING POWER 26,666,667* ------------------- ---- -------------------------------------------- -------------------------------------------- EACH REPORTING 7. SOLE DISPOSITIVE POWER 0 ------------------- ---- -------------------------------------------- -------------------------------------------- PERSON WITH: 8. SHARED DISPOSTIVE POWER 26,666,667* ------------------- ---- -------------------------------------------- -------------------------------------------- --------- ------------------------------------------------------------------------- ------------------------------ 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 26,666,667* --------- ------------------------------------------------------------------------- ------------------------------ --------- -------------------------------------------------------------------------------------------------------- 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) [ ] -------------------------------------------------------------------------------------------------------- --------- ------------------------------------------------------------------------- ------------------------------ 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 13.3%* --------- ------------------------------------------------------------------------- ------------------------------ 12. TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) IA --------- ------------------------------------------------------------------------- ------------------------------

-------------------------------------- ------------------------------------- ------------------------------------- CUSIP No. 00202J203 13G Page 3 of 7 Pages -------------------------------------- ------------------------------------- ------------------------------------- 13. NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) JOSEPH EDELMAN --------- -------------------------------------------------------------------------------------------------------- 14. CHECK THE APPROPRIATE BOX IF A GROUP* (a) [ ] (b) [ ] --------- -------------------------------------------------------------------------------------------------------- 15. SEC USE ONLY --------- -------------------------------------------------------------------------------------------------------- 16. CITIZENSHIP OR PLACE OF ORGANIZATION UNITED STATES OF AMERICA --------- -------------------------------------------------------------------------------------------------------- NUMBER OF SHARES 17. SOLE VOTING POWER 0 ------------------- ---- -------------------------------------------- -------------------------------------------- BENEFICIALLY OWNED BY 18. SHARED VOTING POWER 26,666,667* ------------------- ---- -------------------------------------------- -------------------------------------------- EACH REPORTING 19. SOLE DISPOSITIVE POWER 0 ------------------- ---- -------------------------------------------- -------------------------------------------- PERSON WITH: 20. SHARED DISPOSTIVE POWER 26,666,667* ------------------- ---- -------------------------------------------- -------------------------------------------- 21. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 26,666,667* --------- -------------------------------------------------------------------------------------------------------- 22. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) [ ] --------- ------------------------------------------------------------------------- ------------------------------ 23. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 13.3%* --------- ------------------------------------------------------------------------- ------------------------------ 24. TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) IN --------- ------------------------------------------------------------------------- ------------------------------

--------------------------------------- ------------------------------------ -------------------------------------- CUSIP No. 00202J203 13G Page 4 of 7 Pages --------------------------------------- ------------------------------------ -------------------------------------- ITEM 1. (a) Name of Issuer: A.P. PHARMA, INC. 123 SAGINAW DRIVE (b) Address of Issuer's Principal Executive Offices: REDWOOD CITY, CA 94063 ITEM 2. THIS SCHEDULE 13G (THE "SCHEDULE") IS BEING FILED (a) Name of Person Filing: WITH RESPECT TO SHARES OF COMMON STOCK (AS DEFINED BELOW) OF A.P. PHARMA, INC. (THE "ISSUER") WHICH ARE BENEFICIALLY OWNED BY PERCEPTIVE ADVISORS LLC AND JOSEPH EDELMAN (TOGETHER, THE "REPORTING PERSONS"). SEE ITEM 4 BELOW. (b) Address of Principal Business Office or, if none, Residence: 499 PARK AVENUE, 25TH FLOOR NEW YORK, NY 10022 (c) Citizenship: PERCEPTIVE ADVISORS LLC IS A DELAWARE LIMITED LIABILITY COMPANY AND JOSEPH EDELMAN IS A UNITED STATES CITIZEN. (d) Title of Securities: Class of COMMON STOCK (e) CUSIP Number: 00202J203 ITEM 3. IF THIS STATEMENT IS FILED PURSUANT TO ss.ss.240.13D-1(B) OR 240.13D-2(B) OR (C), CHECK WHETHER THE PERSON FILING IS A: (a) [ ] Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o). (b) [ ] Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c). (c) [ ] Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c). ( d) [ ] Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C 80a-8). (e) [X] An investment adviser in accordance with ss.240.13d-1(b)(1)(ii)(E); (f) [ ] An employee benefit plan or endowment fund in accordance with ss.240.13d-1(b)(1)(ii)(F); (g) [ ] A parent holding company or control person in accordance with ss. 240.13d-1(b)(1)(ii)(G); (h) [ ] A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813); (i) [ ] A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3); (j) [ ] Group, in accordance with ss.240.13d-1(b)(1)(ii)(J).

--------------------------------------- ------------------------------------ -------------------------------------- CUSIP No. 00202J203 13G Page 5 of 7 Pages --------------------------------------- ------------------------------------ -------------------------------------- ITEM 4. OWNERSHIP. Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1. The Reporting Persons beneficially own 26,666,667* shares of Common Stock held by a private investment fund to which Perceptive (a) Amount beneficially owned: Advisors LLC serves as the investment manager. Mr. Edelman is the managing member of Perceptive Advisors LLC. The beneficial ownership of 13.3% is based on the sum of (i) 40,017,790 shares of Common Stock issued and outstanding as of June 30, 2011 as reflected on the Issuer's 8-K on June 30, 2011, and (ii) 160,000,006 shares of Common Stock issued pursuant to the Securities Purchase Agreement filed with the Issuer's 8-K on June 30, 2011.* *Excludes 13,333,333.5 shares underlying Common Stock purchase warrants held by the Reporting Persons. The warrants are not presently exercisable due to an (b) Percent of class: exercisability limitation included in the Warrant which provides that the warrants are not exercisable (i) while the holder is a beneficial owner of over 9.99 % of the shares of the Issuer or (ii) to the extent that such exercise would cause the holder's beneficial ownership to exceed 9.99%. (c) Number of shares as to which the person has: (i) Sole power to vote or to direct the vote: 0 (ii) Shared power to vote or to direct the vote: 26,666,667* (iii) Sole power to dispose or to direct the disposition of: 0 (iv) Shared power to dispose or to direct the disposition of: 26,666,667* ITEM 5 Ownership of Five Percent or Less of a Class If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following: [_]. ITEM 6 Not Applicable Filing of this statement by the Reporting Persons shall not be deemed an admission that they beneficially own the securities reported herein. The Reporting Persons expressly disclaim beneficial ownership of all securities reported herein. ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY OR CONTROL PERSON. Not applicable.

-------------------------------------- ------------------------------------- ------------------------------------- CUSIP No. 00202J203 13G Page 6 of 7 Pages -------------------------------------- ------------------------------------- ------------------------------------- ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP. Not applicable. ITEM 9. NOTICE OF DISSOLUTION OF GROUP. Not applicable. ITEM 10. CERTIFICATION The following certification shall be included if the statement is filed pursuant to ss.240.13d-1(b): By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held (a) for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. [X]

--------------------------------------- ------------------------------------ ------------------------------------- CUSIP No. 00202J203 13G Page 7 of 7 Pages --------------------------------------- ------------------------------------ ------------------------------------- SIGNATURE After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. --------------------------------------- ------------------------------------ ------------------------------------- July 7, 2011 Date PERCEPTIVE ADVISORS LLC /s/ Joseph Edelman Signature Joseph Edelman/Managing Member Name/Title July 7, 2011 Date /s/ Joseph Edelman Signature Joseph Edelman Name/Title --------------------------------------- ------------------------------------ ------------------------------------- The original statement shall be signed by each person on whose behalf the statement is filed or his authorized representative. If the statement is signed on behalf of a person by his authorized representative other than an executive officer or general partner of the filing person, evidence of the representative's authority to sign on behalf of such person shall be filed with the statement, provided, however, that a power of attorney for this purpose which is already on file with the Commission may be incorporated by reference. The name and any title of each person who signs the statement shall be typed or printed beneath his signature. NOTE: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See ss.240.13d-7 for other parties for whom copies are to be sent. ATTENTION: INTENTIONAL MISSTATEMENTS OR OMISSIONS OF FACT CONSTITUTE FEDERAL CRIMINAL VIOLATIONS (SEE 18 U.S.C. 1001)