OMB
APPROVAL
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OMB
Number: 3235-0145
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Expires:
February 28, 2009
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Estimated
average burden
hours
per response. . . 10.4
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[
]
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Rule
13d-1(b)
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[X]
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Rule
13d-1(c)
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[
]
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Rule
13d-1(d)
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CUSIP
No. 00202J203
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13G
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Page 2 of 8 Pages
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||||
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1.
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Names
of Reporting Persons.
I.R.S.
Identification Nos. of above persons (entities only).
RA Capital Management,
LLC
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||||
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||||||
2.
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Check
the Appropriate Box if a Member of a Group (See
Instructions)
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|||||
(a)
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o | |||||
(b)
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o | |||||
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||||||
3.
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SEC
Use Only
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|||||
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||||||
4.
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Citizenship
or Place of
Organization
Massachusetts
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|||||
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||||||
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
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5.
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Sole
Voting
Power 0
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||||
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||||||
6.
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Shared
Voting
Power 0
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|||||
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||||||
7.
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Sole
Dispositive
Power 0
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|||||
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||||||
8.
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Shared
Dispositive
Power 0
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|||||
|
||||||
9.
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Aggregate
Amount Beneficially Owned by Each Reporting Person
0
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|||||
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||||||
10.
|
Check
if the Aggregate Amount in Row (9) Excludes o
Certain
Shares (See Instructions)
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|||||
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||||||
11.
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Percent
of Class Represented by Amount in Row (9)
0.0%
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|||||
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||||||
12.
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Type
of Reporting Person (See Instructions)
IA
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|||||
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CUSIP
No. 00202J203
|
13G
|
Page
3 of 8 Pages
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||||
|
||||||
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1.
|
Names
of Reporting Persons.
I.R.S.
Identification Nos. of above persons (entities only).
Peter
Kolchinsky
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||||
|
||||||
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
|||||
(a)
|
o | |||||
(b)
|
o | |||||
|
||||||
3.
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SEC
Use Only
|
|||||
|
||||||
4.
|
Citizenship
or Place of
Organization United
States
|
|||||
|
||||||
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
5.
|
Sole
Voting
Power 0
|
||||
|
||||||
6.
|
Shared
Voting Power 0
|
|||||
|
||||||
7.
|
Sole
Dispositive
Power 0
|
|||||
|
||||||
8.
|
Shared
Dispositive
Power 0
|
|||||
|
||||||
9.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person
0
|
|||||
|
||||||
10.
|
Check
if the Aggregate Amount in Row (9) Excludes o
Certain
Shares (See Instructions)
|
|||||
|
||||||
11.
|
Percent
of Class Represented by Amount in Row (9)
0.0%
|
|||||
|
||||||
12.
|
Type
of Reporting Person (See Instructions)
IN
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|||||
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CUSIP
No. 00202J203
|
13G
|
Page
4 of 8 Pages
|
||||
|
||||||
|
1.
|
Names
of Reporting Persons.
I.R.S.
Identification Nos. of above persons (entities only).
RA Capital Healthcare Fund,
L.P.
|
||||
|
||||||
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
|||||
(a)
|
o | |||||
(b)
|
o | |||||
|
||||||
3.
|
SEC
Use Only
|
|||||
|
||||||
4.
|
Citizenship
or Place of
Organization
Delaware
|
|||||
|
||||||
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
5.
|
Sole
Voting
Power 0
|
||||
|
||||||
6.
|
Shared
Voting Power 0
|
|||||
|
||||||
7.
|
Sole
Dispositive
Power 0
|
|||||
|
||||||
8.
|
Shared
Dispositive
Power 0
|
|||||
|
||||||
9.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person
0
|
|||||
|
||||||
10.
|
Check
if the Aggregate Amount in Row (9) Excludes o
Certain
Shares (See Instructions)
|
|||||
|
||||||
11.
|
Percent
of Class Represented by Amount in Row (9)
0.0%
|
|||||
|
||||||
12.
|
Type
of Reporting Person (See Instructions)
PN
|
|||||
|
CUSIP
No. 00202J203
|
13G
|
Page
5 of 8 Pages
|
||||
|
||||||
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1.
|
Names
of Reporting Persons.
I.R.S.
Identification Nos. of above persons (entities only).
RA Capital Healthcare Fund II,
L.P.
|
||||
|
||||||
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
|||||
(a)
|
o | |||||
(b)
|
o | |||||
|
||||||
3.
|
SEC
Use Only
|
|||||
|
||||||
4.
|
Citizenship
or Place of
Organization Delaware
|
|||||
|
||||||
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
5.
|
Sole
Voting
Power 0
|
||||
|
||||||
6.
|
Shared
Voting Power 0
|
|||||
|
||||||
7.
|
Sole
Dispositive
Power 0
|
|||||
|
||||||
8.
|
Shared
Dispositive
Power 0
|
|||||
|
||||||
9.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person
0
|
|||||
|
||||||
10.
|
Check
if the Aggregate Amount in Row (9) Excludes o
Certain
Shares (See Instructions)
|
|||||
|
||||||
11.
|
Percent
of Class Represented by Amount in Row (9)
0.0%
|
|||||
|
||||||
12.
|
Type
of Reporting Person (See Instructions)
PN
|
|||||
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CUSIP
No. 00202J203
|
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Page 6 of 8
Pages
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CUSIP
No. 00202J203
|
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Page 7 of 8
Pages
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Item
6.
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Ownership
of More than Five Percent on Behalf of Another
Person:
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CUSIP
No. 00202J203
|
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Page 8
of 8
Pages
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