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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13G


                    UNDER THE SECURITIES EXCHANGE ACT OF 1934

                               (AMENDMENT NO. 4)*


                                A.P. PHARMA, INC.
- --------------------------------------------------------------------------------
                                (Name of Issuer)


                     COMMON STOCK, PAR VALUE $.01 PER SHARE
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                    00202J203
- --------------------------------------------------------------------------------
                                 (CUSIP Number)


                                DECEMBER 31, 2007
- --------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

[ ]   Rule 13d-1(b)

[X]   Rule 13d-1(c)

[ ]   Rule 13d-1(d)


*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

PERSONS WHO RESPOND TO THE COLLECTION OF INFORMATION CONTAINED IN THIS FORM ARE
NOT REQUIRED TO RESPOND UNLESS THE FORM DISPLAYS A CURRENTLY VALID OMB CONTROL
NUMBER.


                                       1

- ------------------- ------------------ CUSIP No. 00202J203 13G/A Page 2 of 10 Pages - ------------------- ------------------ 1. NAMES OF REPORTING PERSONS Great Point Partners, LLC I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY): 37-1475292 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3. SEC USE ONLY - -------------------------------------------------------------------------------- 4. CITIZENSHIP OR PLACE OF ORGANIZATION Delaware NUMBER OF SHARES 5. SOLE VOTING POWER BENEFICIALLY - 0 - OWNED BY EACH 6. SHARED VOTING POWER REPORTING PERSON - 0 - WITH 7. SOLE DISPOSITIVE POWER - 0 - 8. SHARED DISPOSITIVE POWER - 0 - 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON - 0 - 10. CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) [ ] 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 0% 12. TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) 00

- ------------------- ------------------ CUSIP No. 00202J203 13G/A Page 3 of 10 Pages - ------------------- ------------------ 1. NAMES OF REPORTING PERSONS Dr. Jeffrey R. Jay, M.D. I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY): 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3. SEC USE ONLY - -------------------------------------------------------------------------------- 4. CITIZENSHIP OR PLACE OF ORGANIZATION United States NUMBER OF SHARES 5. SOLE VOTING POWER BENEFICIALLY - 0 - OWNED BY EACH 6. SHARED VOTING POWER REPORTING PERSON - 0 - WITH 7. SOLE DISPOSITIVE POWER - 0 - 8. SHARED DISPOSITIVE POWER - 0 - 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON - 0 - 10. CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) [ ] 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 0% 12. TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) IN

- ------------------- ------------------ CUSIP No. 00202J203 13G/A Page 4 of 10 Pages - ------------------- ------------------ 1. NAMES OF REPORTING PERSONS Mr. David Kroin I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY): 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3. SEC USE ONLY - -------------------------------------------------------------------------------- 4. CITIZENSHIP OR PLACE OF ORGANIZATION United States NUMBER OF SHARES 5. SOLE VOTING POWER BENEFICIALLY - 0 - OWNED BY EACH 6. SHARED VOTING POWER REPORTING PERSON - 0 - WITH 7. SOLE DISPOSITIVE POWER - 0 - 8. SHARED DISPOSITIVE POWER - 0 - 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON - 0 - 10. CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) [ ] 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 0% 12. TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) IN

- ------------------- ------------------ CUSIP No. 00202J203 13G/A Page 5 of 10 Pages - ------------------- ------------------ ITEM 1. NAMES OF REPORTING PERSONS (a) Name of Issuer A.P. Pharma, Inc. (the "Company"). (b) Address of Issuer's Principal Executive Offices The Company's principal executive office is located at 123 Saginaw Drive, Redwood City, CA 94063. ITEM 2. (a) Name of Person Filing This Schedule 13G/A is being jointly filed by Great Point Partners, LLC ("Great Point"), Dr. Jeffrey R. Jay and Mr. David Kroin with respect to the ownership of the shares of Common Stock by Biomedical Value Fund, L.P. ("BMVF") and Biomedical Offshore Value Fund, Ltd. ("BOVF"). Dr. Jay, Mr. Kroin and Great Point are referred to in this Schedule G/A as the "Reporting Persons." The Reporting Persons have entered into a Joint Filing Agreement, dated February 14, 2008, a copy of which is filed with this Amendment No. 4 to Schedule 13G/A as Exhibit A, pursuant to which the Reporting Persons have agreed to file this statement jointly in accordance with the provisions of Rule 13d-1(k)(1) under the Act. (b) Address of Principal Business Office, or if none, Residence The address of the principal business office of each of the Reporting Persons is: 165 Mason Street, 3rd Floor Greenwich, CT 06830 (c) Citizenship Great Point is organized as a limited liability company under the laws of the State of Delaware. Dr. Jay is a United States citizen. Mr. Kroin is a United States citizen. (d) Title of Class of Securities Common Stock, par value $.01 per share. (e) CUSIP Number 00202J203 ITEM 3. IF THIS STATEMENT IS FILED PURSUANT TO SS.240.13D-1(b) OR 240.13D.2(b) OR (c), CHECK WHETHER THE PERSON FILING IS A: Not Applicable. (a) [ ] Broker or dealer registered under Section 15 of the Act (15 U.S.C. 78o)

- ------------------- ------------------ CUSIP No. 00202J203 13G/A Page 6 of 10 Pages - ------------------- ------------------ (b) [ ] Bank as defined in Section 3(a)(6) of the Act (15 U.S.C. 78c). (c) [ ] Insurance company as defined in Section 3(a)(19) of the Act (15. U.S.C. 78c). (d) [ ] Investment Company registered under Section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8). (e) [ ] An investment adviser in accordance with ss.240.13d-1(b)(1)(ii)(E). (f) [ ] An employee benefit plan or endowment fund in accordance with ss.240.13d-1(b)(1)(ii)(F). (g) [ ] A parent holding company or control person in accordance with ss.240.13d-1(b)(1)(ii)(G). (h) [ ] A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813). (i) [ ] A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3). (j) [ ] Group, in accordance with ss.240.13d-1(b)(1)(ii)(J). ITEM 4. OWNERSHIP Great Point Partners, LLC ("Great Point") is the investment manager of Biomedical Value Fund, L.P. ("BVF"), and by virtue of such status may be deemed to be the beneficial owner of the shares of Common Stock of the Issuer owned by BVF (the "BVF Shares"). Each of Dr. Jeffrey R. Jay, M.D. ("Dr. Jay"), as senior managing member of Great Point, and Mr. David Kroin ("Mr. Kroin"), as special managing member of Great Point, has voting and investment power with respect to the BVF Shares, and therefore may be deemed to be the beneficial owner of the BVF Shares. Great Point is the investment manager of Biomedical Offshore Value Fund, Ltd. ("BOVF"), and by virtue of such status may be deemed to be the beneficial owner of shares of Common Stock of the Issuer owned by BOVF (the "BOVF Shares"). Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special managing member of Great Point, has voting and investment power with respect to the BOVF Shares, and therefore may be deemed to be the beneficial owner of the BOVF Shares. Great Point, Dr. Jay and Mr. Kroin disclaim beneficial ownership of the BVF Shares and the BOVF Shares, except to the extent of their respective pecuniary interest. Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1. 1. GREAT POINT PARTNERS, LLC (a) Amount beneficially owned - 0 - (b) Percent of class: 0%. (c) Number of shares as to which the person has: (i) Sole power to vote or to direct the vote - 0 - (ii) Shared power to vote or to direct the vote: - 0 -

- ------------------- ------------------ CUSIP No. 00202J203 13G/A Page 7 of 10 Pages - ------------------- ------------------ (iii) Sole power to dispose or to direct the disposition of - 0 -. (iv) Shared power to dispose or to direct the disposition of: - 0 - 2. DR. JEFFREY R. JAY (a) Amount beneficially owned: - 0 - (b) Percent of class: 0%. (c) Number of shares as to which the person has: (i) Sole power to vote or to direct the vote - 0 - (ii) Shared power to vote or to direct the vote - 0 - (iii) Sole power to dispose or to direct the disposition of - 0 -. (iv) Shared power to dispose or to direct the disposition of: - 0 - 3. MR. DAVID KROIN (a) Amount beneficially owned: - 0 - (b) Percent of class: 0%. (c) Number of shares as to which the person has: (i) Sole power to vote or to direct the vote - 0 - (ii) Shared power to vote or to direct the vote - 0 - (iii) Sole power to dispose or to direct the disposition of - 0 -. (iv) Shared power to dispose or to direct the disposition of: - 0 - ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS If this statement is being filed to report the fact that as of the date hereof each of the Reporting Persons has ceased to be the beneficial owner of more than five percent of the class of securities, check the following [X]. ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON: See response to Item 4. ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY Not Applicable.

- ------------------- ------------------ CUSIP No. 00202J203 13G/A Page 8 of 10 Pages - ------------------- ------------------ ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP Not applicable. ITEM 9. NOTICE OF DISSOLUTION OF GROUP Not applicable. ITEM 10. CERTIFICATION By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as participant in any transaction having that purpose or effect.

- ------------------- ------------------ CUSIP No. 00202J203 13G/A Page 9 of 10 Pages - ------------------- ------------------ SIGNATURE --------- After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Date: February 14, 2008 Great Point Partners, LLC By: /s/ Dr. Jeffrey R. Jay ---------------------------------- Name: Dr. Jeffrey R. Jay ---------------------------------- Its: Senior Managing Member ---------------------------------- /s/ Dr. Jeffrey R. Jay ---------------------------------------- Dr. Jeffrey R. Jay, Individually /s/ Mr. David Kroin ---------------------------------------- Mr. David Kroin, Individually

EXHIBIT A AGREEMENT REGARDING THE JOINT FILING OF SCHEDULE 13G/A The undersigned hereby agree as follows: (i) Each of them is individually eligible to use the Schedule 13G/A to which this Exhibit is attached, and such Schedule 13G/A is filed on behalf of each of them; and (ii) Each of them is responsible for the timely filing of such Schedule 13G/A and any amendments thereto, and for the completeness and accuracy of the information concerning such person contained therein; but none of them is responsible for the completeness or accuracy of the information concerning the other persons making the filing, unless such person knows or has reason to believe that such information is inaccurate. Date: February 14, 2008 Great Point Partners, LLC By: /s/ Dr. Jeffrey R. Jay ---------------------------------- Name: Dr. Jeffrey R. Jay ---------------------------------- Its: Senior Managing Member ---------------------------------- /s/ Dr. Jeffrey R. Jay ---------------------------------------- Dr. Jeffrey R. Jay, individually /s/ Mr. David Kroin ---------------------------------------- Mr. David Kroin, Individually